Series A
$50M
Flagship Pioneering · Lead
Open roles0
Total raised$50M
Team size1-10
Founded · Stage2021 · Series A
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About the company
What they build and who they serve.
Serif Biomedicines is a Cambridge, Massachusetts-based biotechnology company developing Modified DNA as a new therapeutic class. Founded in 2021 within Flagship Labs and emerged from stealth in April 2026, Serif combines chemically modified DNA with mRNA co-factors and lipid nanoparticles to enable programmable, redosable gene expression without altering the genome. The platform targets rare diseases and immune programming and is protected by more than 20 patent families.
Why it matters
Signals from funding, traction, and product direction.
- Sole investor at launch: Flagship Pioneering committed the full $50M as Serif emerged from five years of stealth platform development inside Flagship Labs (founded 2021).
- Modified DNA platform is protected by more than 20 patent families, including issued U.S. patents, covering chemical modifications, mRNA co-factors, and lipid nanoparticle delivery.
- Preclinical data to be presented at an upcoming scientific meeting show tolerability in non-human primates and durable gene expression with functional and therapeutic effects after systemic IV administration.
- Co-founders include Flagship CEO Noubar Afeyan, General Partner Geoffrey von Maltzahn (Board Chair), Eric Keen, and Louisa Helms; advisors include former Alnylam CEO John Maraganore and Generate Biomedicines CEO Mike Nally. Team is approximately 50 employees at launch.
Funding history
Rounds and investors over time, newest first.
In the news
Press, announcements, and coverage about this company.
Investors
Flagship Pioneering
Focus areas
BiotechnologyClinical TrialsGenomicsHealthtechSynthetic Biology
No open roles on the board yet
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