JOB DETAILS

Chief of Staff

CompanyGrafton Sciences
LocationSan Francisco
Work ModeOn Site
PostedDecember 6, 2025
About The Company
Grafton Sciences is pioneering AI systems with general physical ability, the capacity to experiment, engineer, or manufacture anything. By pairing this physical substrate with advanced learning architectures, our goal is to build superintelligence. Backed by leading partners, including ARPA-H, we are redefining how the physical world is queried at scale.
About the Role

About Grafton Sciences

We’re building AI systems with general physical ability, the capacity to experiment, engineer, or manufacture anything. We believe achieving this is a key step toward building superintelligence. With deep technical roots and real-world progress at scale (for example, a $42 million NIH program), we’re pushing the frontier of physical AI. Joining us means inventing from first principles, owning real systems end to end, and helping build a capability the world has never had before.

About The Role

We’re looking for a Chief of Staff who operates as an extension of the CEO—someone who removes obstacles, drives clarity, and ensures the company is moving fast. This is a high-leverage, high-trust role for an individual with strong technical intuition, exceptional execution ability and a founder-type mindset.

Responsibilities

  • Serve as the CEO’s right hand, taking on anything that blocks the company, with enough technical depth to meaningfully operate in a deep-tech environment.

  • Own whatever is bottlenecking you that day: research, modeling, recruiting support, vendors, docs, process, investor prep

  • Run cross-functional projects that cut across hardware, software, operations, and fundraising

  • Take rough requests from you and turn them into structured plans, then execute

  • Build and maintain internal coordination systems so the company “runs like a machine”

Qualifications

  • Very high throughput, biased to action

  • Technical background preferred, Ideally in the fields of CS, physics, biology, chemistry, or synthesis

  • Founder-type mindset: willing to do anything, not precious about scope

  • Comfortable in chaos and incomplete information

  • Learns new domains quickly (finance, legal, ops, whatever is needed)

Above all, we look for candidates who can demonstrate world-class excellence

Key Skills
Technical IntuitionExecution AbilityFounder-Type MindsetResearchModelingRecruiting SupportVendor ManagementProcess ImprovementInvestor PreparationCross-Functional Project ManagementInternal CoordinationLearning New DomainsHigh ThroughputBias to ActionComfort in ChaosDeep-Tech Environment
Categories
TechnologyManagement & LeadershipEngineeringScience & Research
Job Information
📋Core Responsibilities
The Chief of Staff will serve as the CEO’s right hand, addressing any obstacles that hinder the company's progress. They will manage cross-functional projects and ensure the company operates efficiently.
📋Job Type
full time
📊Experience Level
5-10
💼Company Size
5
📊Visa Sponsorship
No
💼Language
English
🏢Working Hours
40 hours
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