JOB DETAILS

Scientist I, Medicinal Chemistry

CompanyVividion Therapeutics, Inc
LocationSan Diego
Work ModeOn Site
PostedFebruary 26, 2026
About The Company
Vividion Therapeutics, Inc. is a biotechnology company focused on transforming the future of human health through the creation of highly selective small molecule medicines that drug traditionally inaccessible targets. The company is advancing a broad, diversified pipeline of multiple, selective small molecule therapeutics for highly sought-after disease-causing target proteins in oncology and immunology. The company’s cutting-edge platform was spun out of the labs of Vividion’s scientific founders, a team of experts in chemical biology and synthetic chemistry from The Scripps Research Institute in La Jolla, CA.
About the Role

Description

Company Overview:


Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.


We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.


Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025.


Job Summary:


As a scientist in the chemistry department, the successful candidate will contribute to the growth of Vividion’s proprietary drug discovery platform through the practice of standard and cutting edge synthetic organic chemistry in the context of drug discovery.  The preferred candidate will be comfortable balancing the use of traditional approaches and exploring novelty on the cutting edge of modern small-molecule drug discovery.

Requirements

Experience and education requirements:

  • PhD +/- post doctoral experience in synthetic organic chemistry
  • 0-3 years of relevant pharmaceutical industry chemistry experience
  • Clear understanding of all relevant reaction mechanisms
  • A clear command of classical and state-of-the-art synthetic methodology coupled with proven hands-on experience
  • Highly productive in the lab along with comfort using modern laboratory technologies

Required Key Attributes: 

  • Curiosity and a strong commitment to continuous learning
  • Effective team Player 
  • Solid problem-solving and communication skills
  • Creativity
  • Focus, attention to details, and a willingness to challenge dogma 

Pay & Benefits: 


The anticipated base salary for this position ranges from $115,000 to $125,000 depending on relevant skills, competencies, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance. 


EEO & Employment Eligibility:


Vividion Therapeutics, Inc. is an equal opportunity employer. All applicants will receive consideration for employment without regard to disability or veteran status.


Privacy Policy:


The protection of your personal information is a commitment we take seriously. For information regarding our Privacy Policy (CA candidates) please visit https://vividion.com/privacy-notice/.

Key Skills
Synthetic Organic ChemistryDrug DiscoveryChemical ProteomicsProteome-Wide FootprintingScreeningIdentificationOptimizationSmall-Molecule Drug DiscoveryReaction MechanismsSynthetic MethodologyLaboratory TechnologiesProblem-SolvingCreativityTeamworkAttention To Details
Categories
Science & ResearchHealthcareEngineering
Benefits
Target BonusLong-term Incentives401k Retirement Savings Plan With Company MatchMedical InsuranceDental InsuranceVision InsuranceLife InsuranceDisability Insurance
Job Information
📋Core Responsibilities
The successful candidate will contribute to the growth of Vividion’s proprietary drug discovery platform by practicing standard and cutting-edge synthetic organic chemistry within the context of drug discovery. This role requires balancing traditional approaches with exploring novelty at the forefront of modern small-molecule drug discovery.
📋Job Type
full time
💰Salary Range
$115,000 - $125,000
📊Experience Level
0-2
💼Company Size
267
📊Visa Sponsorship
No
💼Language
English
🏢Working Hours
40 hours
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