JOB DETAILS
Scientist Downstream Processing (R&D) (m/f/x)
CompanyLenioBio GmbH
LocationAachen
Work ModeOn Site
PostedOctober 23, 2026
About The Company
ALiCE is a universal protein expression platform for teams who can't wait. Made for AI-designed and complex proteins, ALiCE can produce full length proteins, with eukaryotic modifications, within hours.
If you are:
- Stuck waiting for wet lab data to feed into your model
- Working with complex, toxic, or non-natural proteins
- Fed up of testing multiple cell lines and expression systems
Get in touch with LenioBio to learn more about how ALiCE can support you
About the Role
About LenioBio
At LenioBio, we believe everyone deserves access to better medicines and a healthier future.To make this possible, we are transforming how therapeutic proteins are developed and manufactured. Our proprietary ALiCE® technology enables faster, more efficient, and more sustainable protein production, helping bring life-changing medicines to patients around the world.
We are on an exciting growth journey and are looking for curious, passionate, and entrepreneurial individuals who want to make a meaningful impact. If you're excited about breakthrough science, solving complex challenges, and helping build the future of biomanufacturing, we'd love to hear from you.
Everything we do starts with our mission: empowering our partners and customers with disruptive technologies that make protein production faster, simpler, more scalable, and more cost-effective.
ALiCE® is a scalable end-to-end protein expression platform that supports the entire pharmaceutical development pathway, from early discovery and preclinical research through process development and manufacturing.
Our vision is to unlock the full potential of ALiCE® and accelerate access to innovative protein-based medicines by reducing development timelines, lowering production costs, and expanding manufacturing possibilities worldwide.
Why Join LenioBio?
- Work on cutting-edge biotechnology with real-world impact.
- Join a growing and ambitious team where your ideas matter.
- Take ownership and help shape the future direction of the company.
- Collaborate with talented scientists, innovators, and industry experts.
- Contribute to a mission that has the potential to improve healthcare globally.
About This Job
The Downstream Processing Scientist is responsible for developing, optimizing, and scaling purification processes for proteins and biologics produced using LenioBio's ALiCE® technology platform. The role bridges early-stage research and manufacturing by advancing molecules from discovery through process development, scale-up, and technology transfer, while ensuring product quality, scalability, and project success. Working closely with R&D, Analytics, Technical Operations, and external CDMO partners, the scientist drives scientific innovation and contributes to the successful delivery of customer and internal development programs.
What Your Responsibilities Are
- Design, develop, optimize, and transfer downstream purification processes for research and development programs.
- Independently plan, execute, analyze, and interpret downstream process development studies.
- Evaluate and implement innovative purification technologies, chromatography approaches, and membrane-based processes.
- Support process scale-up and technology transfer activities with manufacturing partners and CDMOs.
- Apply scientific expertise to customer discussions, project proposals, grant activities, and business development initiatives.
- Communicate project progress, experimental findings, risks, and recommendations to stakeholders.
- Author technical reports, SOPs, study summaries, protocols, and quality documentation.
- Mentor students, technical assistants, and junior scientists.
- Drive scientific troubleshooting and continuous improvement initiatives.
What We're Looking For
Qualifications & Scientific Expertise- MSc or PhD in Biochemistry, Biotechnology, Bioprocess Engineering, or a related life science discipline.
- Strong expertise in downstream process development, protein purification, chromatography, and scale-up of biologics.
- Hands-on experience with ÄKTA systems, affinity purification technologies, and protein characterization methods (e.g., HPLC, SEC, ELISA, BLI/SPR).
- 3+ years of industry experience in biotechnology, biopharma, or CDMO environments.
- Strong scientific problem-solving, data analysis, and technical writing skills.
- Understanding of upstream process development is an advantage.
- Proven ability to independently design, execute, and interpret complex process development studies.
- Experience supporting process scale-up and technology transfer activities.
- Strong project management and prioritization skills.
- Ability to communicate scientific results effectively to technical and non-technical stakeholders.
- Collaborative mindset with experience working across multidisciplinary teams and mentoring junior colleagues.
- Passion for solving complex scientific and technical challenges.
- Independent, analytical, and data-driven thinker.
- Adaptable, resilient, and proactive, with a hands-on approach.
- Self-motivated and comfortable working in a dynamic biotech environment.
- Committed to scientific excellence, quality, and continuous improvement.
- Professional fluency in English, both written and spoken.
- Willingness to work primarily on-site in Aachen and collaborate closely with laboratory-based teams.
You'll be successful in this role if you...
- Enjoy turning challenging purification problems into scalable solutions.
- Thrive in a hands-on laboratory environment while maintaining a strategic perspective.
- Take ownership and proactively drive projects forward.
- Excel in collaborative, fast-paced, cross-functional teams.
- Want to contribute to innovative biologics enabled by LenioBio's ALiCE® platform.
What We Offer
- A full-time position in Aachen, Germany, offered on a two-year project-based contract.
- The opportunity to shape the future of biomanufacturing. Join a pioneering biotech company that is transforming protein production and helping accelerate access to innovative medicines worldwide.
- A role in which you can take ownership of challenging scientific projects with significant growth opportunities.
- A dynamic and entrepreneurial environment where innovation is encouraged, initiative is valued, and bureaucracy is kept to a minimum.
- The chance to work alongside a diverse, international, and highly talented team united by a shared passion for scientific excellence and innovation.
- Professional and personal growth opportunities in a fast-paced organization.
- A competitive compensation package that recognizes your expertise, contribution, and impact.
- A culture built on collaboration, trust, and continuous learning, where open communication and constructive feedback are encouraged at every level.
Contact us
Ready to make an impact?We look forward to receiving your application and learning how your expertise can contribute to the future of protein expression at LenioBio.
Apply now and become part of the LenioBio team:
Please click on "Apply" and upload your documents or send us an e-mail to careers@leniobio.com.
About us
At LenioBio, we're not just a biotechnology company—we're pioneers on a mission to revolutionize how complex proteins are produced, enabling faster, more efficient drug discovery and manufacturing. Our groundbreaking ALiCE technology is redefining the boundaries of what’s possible in protein engineering, enabling the rapid, scalable, and efficient production of complex proteins that are at the forefront of medical innovation. Divided between our headquarters Düsseldorf, Germany, with our innovation hub in Aachen, we’re a dynamic and innovative team committed to pushing the boundaries of science and making a tangible impact on healthcare.
As we’re focused on expanding ALiCE’s capabilities to meet the evolving needs of the biopharmaceutical industry, we’re looking for passionate, talented individuals to join us on this exciting journey. At LenioBio, you’ll be part of a collaborative and forward-thinking environment where your contributions are valued, and your growth is supported. Join us and be a part of something truly groundbreaking.
Key Skills
Downstream process developmentProtein purificationChromatographyScale-upBiologicsÄKTA systemsAffinity purificationProtein characterizationHPLCSECELISABLI/SPRTechnical writingProject managementTroubleshootingData analysis
Categories
Science & ResearchManufacturingHealthcareEngineering
Benefits
Professional growth opportunitiesPersonal growth opportunitiesCompetitive compensation packageCollaborative work environment
Job Information
📋Core Responsibilities
The scientist will design, develop, and optimize downstream purification processes for proteins produced using the ALiCE platform. They will also manage process scale-up, technology transfer, and cross-functional collaboration with internal teams and external partners.
📋Job Type
fixed term
📊Experience Level
2-5
💼Company Size
47
📊Visa Sponsorship
No
💼Language
English
🏢Working Hours
40 hours
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