(Sr) Director, Translational Sciences

(Sr) Director, Translational Sciences

Job Description

LTZ is looking for an experienced (Sr)Director, Translational Sciences to join our energetic and high-performance team. Under the direction of the Chief Scientific Officer, and in collaboration with the Clinical/Medical, Preclinical and Discovery teams, and external KOLs, the (Sr)Director, Translational Sciences will lead our biomarker discovery efforts in support of development and execution of clinical development plans and indication/patient selection strategies. Based in Shenzhen China, the incumbent will be a vital part of shaping our translational strategy and vision.

Key responsibilities
Provides scientific leadership in areas of biomarker discovery, development and translational science working with multiple cross-functional teams
Collaborate with Preclinical Development, Clinical Operations teams and external experts as appropriate to develop scientifically rigorous translational and exploratory biomarker strategies that assess proof of mechanism, establish early signs of efficacy, enable proof of concept studies, patient selection and generate an understanding of the variability in patient response
Partner with preclinical and drug discovery scientists to design and execute translational research to discover and validate pathways and biomarkers associated with mechanism of action and drug response
Support scientific input and review of all translational medicine aspects of clinical and regulatory documents, including but not limited to development plans, study protocols, clinical study reports, regulatory submissions and responses to any regulatory questions, etc.
Propose and develop innovative methods and technologies as well as new directions for project development
Function as a scientific and business thought-leader inside and outside of the company and a key link to external scientific & medical community.

Qualifications
PhD (and/or MD) with primary focus in either Cellular or Molecular Biology, Immunology, Cancer Biology and/or Pharmacology with at least 8 years of pharmaceutical or biotechnology industry experience in biomarker discovery and companion diagnostics
Thorough understanding of clinical trials and clinical strategy, experience with cancer immunotherapy development as well as analytical and clinical validation of biomarker assays
First-hand experience with identification and validation of pharmacodynamic and indication/patient selection biomarkers and clinical implementation
Ability to drive and influence projects from discovery through early clinical development with a focus on the identification of indications with biomarkers of response and/or resistance to therapy
Expertise in establishing and running preclinical studies
Familiarity with data management and visualization tools and collaborating with computational biology to analyze complex genomic data sets Passion for developing new therapies

Competencies
Outstanding analytical, research and organizational skills
Strong interpersonal, influencing and collaboration skills to work in a team-oriented, fast-paced environment
Strong scientific communication skills to diverse audiences, and ability to present the results in a clear and concise manner
Ability to prioritize, be highly productive and flexible in a fast-paced work environment.